The human body is not designed to withstand such extreme pressures. If a person were to descend to the bottom of the Mariana Trench, their body would be subjected to a force that is equivalent to the weight of several elephants pressing down on them. This pressure would cause their bones to break, their lungs to collapse, and their blood vessels to burst.
Even if a person were able to survive the initial descent, they would not be able to stay at the bottom of the trench for very long. The extreme cold, lack of oxygen, and total darkness would quickly take their toll, and they would eventually die.
In conclusion, it is not possible for a person to survive a trip to the bottom of the Mariana Trench. The pressure, cold, lack of oxygen, and total darkness would all quickly kill them.