How much time does it take to reach Karachi from Islamabad by bus?

There is no direct bus route from Islamabad to Karachi. However, there are several indirect routes that can be taken, with journey times varying depending on the route taken and the number of stops made. The shortest route, via Lahore and Multan, takes around 24 hours, while the longest route, via Rawalpindi, Faisalabad, and Bahawalpur, takes around 30 hours.