1. Lexington, Kentucky
* Distance from Knoxville: 280 miles
* Distance from Milwaukee: 410 miles
* Lexington is home to the University of Kentucky, Rupp Arena, and Keeneland Race Course. It's also a great place to stop for bourbon tasting.
2. Indianapolis, Indiana
* Distance from Knoxville: 410 miles
* Distance from Milwaukee: 280 miles
* Indianapolis is the capital of Indiana and home to the Indianapolis 500, the largest single-day sporting event in the world. It's also a great place to visit the Indianapolis Zoo, the Children's Museum of Indianapolis, and the Indiana State Museum.
3. Chicago, Illinois
* Distance from Knoxville: 600 miles
* Distance from Milwaukee: 90 miles
* Chicago is a major city on the shores of Lake Michigan. It's home to world-class museums, art galleries, music venues, and theaters. It's also a great place to visit the Willis Tower, the Field Museum, and the Shedd Aquarium.
Of course, there are many other great places to stop between Knoxville and Milwaukee. These are just a few suggestions to get you started.