The drive from Louisville, Kentucky to Corpus Christi, Texas is approximately 1,300 miles (2,090 km). Estimated driving time: 20–21 hours (non-stop, ideal conditions). Realistically, it's a 2-day trip with an overnight stop (e.g., Dallas, San Antonio). Common route: I-64 W → I-57 S → I-40 W → I-35 S → I-37 S. Traffic, weather, and border patrol checkpoints (I-35/I-37) can add time.