1. Interstate 5: The major north-south route through the state, connecting Portland to California and Washington. It is a major corridor for freight transportation.
2. Interstate 84: Runs east-west through the state and connects Portland with Idaho.
3. Oregon Route 20: Also called the Santiam Highway, runs from Corvallis through Santiam Pass to Bend.
4. Oregon Route 26: Known as the Mount Hood Highway, it extends from Portland to Prineville, passing near Mount Hood.
5. Oregon Route 101: The iconic coastal route, also called the Pacific Coast Highway, runs along the state's Pacific coastline.