The drive from Austin to Odessa is approximately 330 miles (530 km) via the most direct route: I-35 North to US-87 North / US-83 North to I-20 West (or US-290 W to I-10 W to I-20 W). Driving time: 5 to 5.5 hours.
Route highlights: Texas Hill Country (I-35/US-290), West Texas plains, oil field traffic (Permian Basin) near Midland/Odessa—expect heavy trucks. Fuel stops: Fredericksburg, Junction, Sonora, or Big Lake. No major mountain passes.