Head to the nearest big city. Choose a city within driving distance or fly there if it's faster. If you live in a big city, act like a tourist for the weekend. Visit museums, art galleries, historical site and parks. Go see a play or sporting event. Visit friends and take them out for dinner at the best restaurant in town. Check out observation decks to see city lights or the sunset. Go dancing at clubs with friends or people you've met over the course of the day.
Get out of the rat race and retreat to the country. Book a weekend at a bed and breakfast or inn. You can plan a relaxing weekend ahead of time or go for a drive and stop at whatever location looks good to you. Drive to cottage country and rent a cabin. Pick a location where your cell and laptop have no service. If you need to make a call, go to the reception desk; otherwise, you are phone and Internet free.
Whether you go to a big city or a small town, many tourist destinations offer tours. Take a bus or walking tour and learn about your city of choice. Many big cities have a variety of tours to suit your interest. You can take historical tours of important sites and buildings. Restaurant tours allow you to sample food at some of the best restaurants in town. Ghost tours include tales of paranormal activity. Film and television tours show you all the sites where filming took place and buildings and locations that were featured in movies.
Head to whatever wine region is closest to you. Cutting down on travel time means you have more time to relax and enjoy your weekend. Stay at a fancy hotel or a kitschy inn and visit the local wineries. You can get a tour of the grounds and learn how wine is made. Some wineries even let you stomp grapes or sample wine. You can take a wine tasting class and meet other people with the same interests.