Plan your journey to include a stop every couple hours to let your dog out of the car to run and go to the bathroom. Though your dog generally does not go to the bathroom this often, he may be anxious in the car causing a nervous bladder. He will also be calmer if you let him run eto release energy. Truck stops, rest areas and even gas stations in small towns often have places to let your dog out. Be sure to keep your dog on a leash just in case it is a city ordinance.
Keep water and a dish at hand in case your dog is thirsty. It is especially important on a hot day to keep your dog hydrated. When a dog is excited, he may pant and require more water than usual. Ask at drive-thrus for a glass of water for a mess-free way to give your dog a drink. Take the lid off and let him drink from the cup.
Crate your dog in the backseat if he is used to sleeping in a crate. Purchase a travel crate for small dogs that sits on the backseat and takes less space. If he is used to sleeping on his bed, make a pile of pillows and blankets into a bed or purchase a small bed that fits in the car. Make him as comfortable as possible.
Give him a rawhide bone to chew on while in the car or a new toy. This will keep him distracted and calm him if nervous.