How long does it take to fly from St. Louis MO Rome Italy with delays?

There are no direct flights from St. Louis MO to Rome Italy, so any flight will include at least one layover. Depending on the routing, flight time can range from approximately 13.5 hours (including a minimum layover) to over 24 hours, especially if there are additional layovers or flight delays. It's always best to consult with specific airlines or online flight search engines for the latest real-time flight schedules and flight times, as delays and schedules can change.