* 1846: Iowa becomes the 29th state of the United States.
* 1854: The Kansas-Nebraska Act is passed, leading to increased tensions over the issue of slavery in Iowa.
* 1861-1865: Iowa contributes over 75,000 troops to the Union Army during the Civil War.
* 1869: The first transcontinental railroad is completed, passing through Iowa.
* 1873: The Great Depression of 1873 hits Iowa hard, leading to a decline in the state's economy.
* 1893: The World's Columbian Exposition is held in Chicago, Illinois, and Iowa is one of the states represented.
* 1918-1919: The Spanish Flu pandemic kills over 10,000 people in Iowa.
* 1930-1939: The Great Depression hits Iowa hard, leading to a decline in the state's economy and widespread unemployment.
* 1941: Iowa enters World War II after the attack on Pearl Harbor.
* 1954: The Supreme Court rules in Brown v. Board of Education, declaring that segregation of public schools is unconstitutional.
* 1963: Iowa becomes the first state in the United States to enact a state civil rights law.
* 1972: Iowa's first female governor, Rosalynn Carter, is elected.
* 1980: Iowa becomes the first state in the United States to adopt a state law requiring a waiting period before a woman can have an abortion.
* 1993: The Mississippi River floods Iowa, causing extensive damage and economic losses.
* 2001: The September 11 terrorist attacks lead to increased security measures in Iowa.
* 2008: Iowa holds the first-in-the-nation caucus for the Democratic Party's presidential nomination.
* 2019: The state of Iowa legalized same-sex marriage.
* 2020: The COVID-19 pandemic sweeps across the globe, causing widespread illness and economic disruption in Iowa.