The mining industry—especially silver and gold—most fundamentally shaped Spain's 16th-century colonies in Central and South America. Massive deposits at Potosí (Bolivia) and Zacatecas (Mexico) drew Spanish settlers, fueled the crown's wealth, and drove the colonial economy.
Indigenous laborers (under encomienda and mita systems) endured brutal conditions. Mining towns became urban centers, and the influx of precious metals triggered global trade shifts and inflation in Europe (the "Price Revolution").