* Sandia National Laboratories (SNL) is a multi-program laboratory that focuses on national security research, including work in nuclear weapons, homeland security, and cybersecurity. SNL is located in Albuquerque, New Mexico.
* The National Radio Astronomy Observatory (NRAO) operates a number of radio telescopes, including the Very Large Array (VLA) and the Karl G. Jansky Very Large Array (JVLA). The NRAO is headquartered in Charlottesville, Virginia, but has a major facility in Socorro, New Mexico.
* The New Mexico Institute of Mining and Technology (NMIMT) is a public research university that focuses on science, engineering, and technology. NMIMT is located in Socorro, New Mexico.
* The University of New Mexico (UNM) is a public research university with a wide range of research interests, including work in the areas of cancer, genetics, and materials science. UNM is located in Albuquerque, New Mexico.