Which Francisco Left Spain? – Need More Context

"Francisco" is a common Spanish name. No single historical departure is universally notable without further qualification.

Possibilities

• Francisco Pizarro – Sailed to Panama (1513), later Peru (1531).
• Francisco de Orellana – Amazon expedition (1541).
• Francisco Vásquez de Coronado – North American Southwest (1540).
• Francisco Franco – Flew to Morocco (1936) to lead Nationalist uprising.
• Pope Francis (Jorge Bergoglio) – Argentine; never "left Spain" as a historical event.

Please specify which Francisco, era, or event you mean.