- Disease: European diseases, such as smallpox, measles, and influenza, were devastating to the indigenous population of Central Mexico. These diseases were introduced by Spanish conquistadors and spread rapidly through the native communities, often wiping out entire villages.
- Warfare: The Spanish conquest of Mexico was a violent and bloody affair. The Spanish conquistadors, led by Hernán Cortés, engaged in numerous battles with the indigenous peoples, resulting in the deaths of millions of Native Americans.
- Famine: The disruption of traditional agricultural practices and the loss of livestock due to disease and warfare led to widespread famine among the indigenous population.
- Forced labor: The Spanish conquistadors forced many Native Americans into labor, particularly in the mining industry. These workers were often subjected to harsh and dangerous conditions, which contributed to their high mortality rate.
- Cultural genocide: The Spanish conquerors sought to suppress and eradicate indigenous cultures and religious practices. This resulted in the loss of traditional knowledge, languages, and customs, which further destabilized the indigenous communities.
The cumulative effect of these factors resulted in a catastrophic decline in the Native American Indian population of Central Mexico. This population loss had a profound and lasting impact on the region, both demographically and culturally, and its effects can still be felt today.