No. Reno-Tahoe International Airport (RNO) is not a hub for any major U.S. carrier.
It is a focus city / spoke airport served by:
Nonstop destinations include LAX, SFO, LAS, PHX, DEN, SEA, SLC, DFW, IAH, ORD, and seasonal flights to Hawaii, Mexico, Canada. Hubs for these airlines are elsewhere (e.g., Southwest: LAS, PHX, DEN; United: DEN, SFO, ORD).