The longest domestic flight by distance in the U.S. is Honolulu (HNL) to Boston (BOS), at approximately 5,095 miles (8,199 km), with a scheduled time of ~10 hours eastbound.
Other ultra-long domestic routes include:
Correction: The route between Kahului (OGG, Maui) and Hilo (ITO, Big Island) is only ~100 miles (30–40 min flight), not 2,215 miles. The longest inter-island flight in Hawaii is Honolulu to Hilo (~215 mi) or Lihue to Hilo (~240 mi).
Long-haul domestic flights are dominated by routes connecting the mainland to Hawaii, due to the vast Pacific crossing.