- New York City, New York: The Hudson River flows through New York City, separating Manhattan from the rest of the city.
- Chicago, Illinois: The Chicago River flows through the city, dividing it into north and south sides.
- Philadelphia, Pennsylvania: The Delaware River flows along the eastern edge of Philadelphia.
- New Orleans, Louisiana: The Mississippi River flows through New Orleans, dividing the city into the French Quarter and the rest of the city.
- San Antonio, Texas: The San Antonio River flows through the city, passing by historic landmarks such as the Alamo.
- Pittsburgh, Pennsylvania: The Allegheny and Monongahela Rivers meet in Pittsburgh to form the Ohio River.
- Cincinnati, Ohio: The Ohio River flows along the southern edge of Cincinnati.
- Louisville, Kentucky: The Ohio River flows through Louisville, passing by landmarks such as the Louisville Slugger Museum & Factory.
- Memphis, Tennessee: The Mississippi River flows along the western edge of Memphis.
- St. Louis, Missouri: The Mississippi River flows along the eastern edge of St. Louis, dividing the city from Illinois.
