Check the list of approved portable oxygen generators on the Federal Aviation Agency's website to ensure that the model you wish you to take is included on the list. Purchase an updated model which is on the list, if your model is either not approved or does not have the FAA sticker of approval attached. This seal would have been included with purchase of any approved device.
Clean the wheels and exterior of your portable oxygen generator before arriving at the airport. A greasy, oily or dirty piece of machinery may hold up the process.
Contact a representative with the airline at least 48 hours before your scheduled departure time. Special assistance may be required of the airline, and it will make the process go more smoothly to inform them prior to your arrival that you are bringing a portable oxygen generator with you.
Pack enough batteries to operate your portable oxygen generator for the length of the flight plus half. American Airlines defines this as 150% of the flight time. Locate flight time on your itinerary or calculate it from your departure time and scheduled arrival time.
Visit your primary care physican to obtain a letter stating that it is medically necessary for you to take a portable oxygen generator with you during your travels. This document should include statements that you will be able to identify warning lights and sounds, you will respond appropriately in the case of an emergency, the device's flow rate and during what parts of the flight the oxygen is medically required. Refer to the American Airlines sample note for guidance.