If traveling to Vegas with a large group of people, consider chartering a bus from a local company, such as lakefrontlines.com or bluelakes.com. Charter busses tend to safely accommodate about 50 people. They provide a professional driver and usually have restrooms onboard and reclining seats for napping along the way. Discuss your group's specific needs and objectives with the charter bus company; they may be able to organize tours or activities for your group in addition to providing transportation.
If traveling alone or with a smaller group, consider public transportation. The fastest way is to fly from Detroit to Vegas. Spirit Airlines (spirit.com) and Delta Airlines (delta.com) offer direct flights that last about four hours. Greyhound busses (greyhound.com) also travel this route but require stops and transfers making the journey take about two days. A third option is to go by train through Chicago (amtrak.com), which will take about one day.
Once you reach Vegas, you can see the Strip by taking a local bus tour. Lots of options are available, depending on how long you want the tour to be, whether you want to be able to hop on and off of the tour bus, if you want an onboard guide or entertainment, and whether you want to go in the daytime or at night. Bus tours are also available to take you to attractions off the strip, such as to the nearby city of Laughlin in the Colorado River valley or to Disneyland, California.
While Vegas is an exciting destination, there are many Vegas-style casinos to be found right in Michigan. Bus companies around Detroit, such as Travel Treasures and Tours (traveltreasuresandtours.com), offer day and overnight trips to various local casinos. The most lavish Detroit casino is the MGM Grand Detroit, which includes restaurants by Wolfgand Puck and Michael Mina. Staying in Michigan will safe money and time, allowing you to spend more on entertainment.