Option 1: Take I-95 to I-295 around Baltimore. This route is about 245 miles and takes about 4 hours and 30 minutes to drive.
Option 2: Take I-81 to I-76 to I-270 around Baltimore. This route is about 270 miles and takes about 5 hours to drive.
Option 3: Take I-64 to I-81 through West Virginia. This route is about 300 miles and takes about 5 hours and 30 minutes to drive.
Ultimately, the best route to take will depend on your specific starting and ending points and your desired travel time.