The most direct route from Phoenix, AZ to San Antonio, TX covers 872 miles (1,403 km) via I-10 East, taking approximately 13 hours 18 minutes of pure driving time.
Phoenix → (I-10) → Tucson → Las Cruces, NM → El Paso, TX → (Mountain/ Central time zone change) → Van Horn → Fort Stockton → Junction → Kerrville → San Antonio.
I-40 to I-27 to I-20 (northern route) adds ~100 miles but avoids El Paso traffic. US-70/US-54 through White Sands Missile Range area is scenic but slower.
Real-time conditions: DriveTexas.org and AZ511.gov.