- By car: The most direct route is via Interstate 64 West and Interstate 20 West. The estimated travel time is about 15 hours, depending on traffic and weather conditions.
- By air: There are no direct flights between Hampton and Biloxi. The closest major airports to Biloxi are Gulfport-Biloxi International Airport (GPT) and Louis Armstrong New Orleans International Airport (MSY), both of which are about a 1.5-hour drive from the city. The flight time from Hampton to either of these airports is approximately 2 hours and 30 minutes.
- By train: There is no passenger rail service between Hampton and Biloxi. The closest Amtrak station to Biloxi is in Gulfport, Mississippi. The train ride from Hampton to Gulfport takes approximately 22 hours and involves multiple transfers.
- By bus: There are also no direct bus routes between Hampton and Biloxi. The closest Greyhound bus station to Biloxi is in Mobile, Alabama, about a 2-hour drive away. The bus ride from Hampton to Mobile takes about 18 hours and involves multiple transfers.