Choose luggage made from fabrics that do not stain easily. Vinyl soft-sided luggage is easy to wipe off with glass cleaner, laundry detergent or water. Choosing the right fabric could save you a lot of time cleaning your luggage after a flight.
Follow the TSA rules in your checked luggage, as well as with your carry-ons. Lock all liquids and gels inside plastic ziplock bags to avoid spills while traveling. Spills from your own liquids can be one of the biggest culprits, when it comes to stains on your luggage.
Spray an upholstery protector on the outside of your luggage prior to traveling. Even if your bag is then soiled with grease or debris, it will be much easier to remove, if a fabric protector is applied.