Size and weight tend to go hand in hand. When selecting a large suitcase, stick to light fabric materials to offset the larger volume. Hard cases and thick canvas materials are not practical. You will appreciate this difference later, when the bag is packed full.
While luggage with a four-wheel, standing-roll base might seem the most intelligent option, travelers will run into problems if rolling more than one bag at a time this way. The traditional two-wheeled, lean-and-roll suitcase makes it far easier to manage more than one. In either case, make sure wheels are mounted directly to the frame of the luggage, turn freely and without resistance, and have a quiet, smooth roll.
Your suitcase must suit your individual needs. Assess the most convenient shape and capacity for what you must carry, and stick to it. If you need to bring your laptop, look for luggage that has a laptop compartment. If you bring business clothes, find something with a suit bag or equivalent. Make your luggage fit your needs and not the reverse.
While rolling luggage makes your life easier when traveling to most places, it causes difficulty for adventure travelers. Where there is no concrete, wheels will not travel, so your best options are duffel-type bags with removable shoulder straps. These rugged bags can go anywhere, need no delicate treatment, have large and expandable capacity and are available with weatherproof materials.