Zheng He's first voyage departed in 1405, nearly half a century before the Ottoman Turks captured Constantinople in 1453. The Ming admiral led seven massive treasure fleets across the Indian Ocean between 1405 and 1433, reaching Southeast Asia, India, the Persian Gulf, and East Africa. Constantinople's fall to Mehmed II marked the end of the Byzantine Empire and a pivotal shift in Mediterranean power. The temporal gap highlights the concurrent but disconnected expansions of Chinese maritime diplomacy and Ottoman territorial conquest in the early 15th century.