A portion of the downtown area in Iuka was added to the National Register of Historic Places in 1991. Known as the Central Iuka Historic District, it includes all of the structures from Fulton and Main Streets from Eastport Street to the Old Depot at the Southern Railway tracks as well as Front Street from Pearl to Fulton Streets. The district consists of a wide variety of historic buildings that include businesses, department stores, banks and small specialty stores, which are all divided into three periods of significance: 1875 to 1899, 1900 to 1924, and 1925 to 1949.
The city of Iuka includes two historic churches that are both located on Eastport Street that still serve the community: The Iuka Methodist Church and the Church of Our Savior. The Iuka Methodist Church, also known as the Iuka United Methodist Church, was founded in 1859. Its history includes service as a hospital during the Civil War after the Battle of Iuka, where soldiers from both the Union and Confederate Armies were brought to be treated. The Church of Our Savior, founded in 1873, is a Gothic-style church built and designed by architect James B. Cook. It was added to the National Register of Historic Places in 1991.
The city of Iuka includes a total of 55 historic, named homes designed in a wide array of styles. Walnut Port, located on East Meigs Street, is the oldest home in Iuka. Dating back to 1837, it served as both the home of Dr. James Davis during the Civil War and a private school where his daughter, Meg Davis, taught. The Merrill-Nelson home, located on Quitman Street, was built in 1855 and it was the home of the Merrill Family. It is noted for being the birthplace of aviator Dick Merrill, who made the first round-trip, transatlantic flight in 1936. The Moss Rose house, located on North Main Street, dates back to 1845 and it was used as an emergency hospital during the Civil War. During the Battle of Iuka, the structure was severely damaged when a cannon ball penetrated the roof.
The city of Iuka includes two historic public buildings: the Old Tishomingo County Courthouse and the Iuka Public Library. Located on the corner of Quitman and Liberty Streets, the courthouse was built in 1888 and it served as the primary county courthouse until 1971. It was added to the National Register of Historic Places in 1973. The Iuka Public Library on Main Street has operated since the early 1930s and it is noted for being the first non-segregated library in Mississippi.
