The Cumberland Gap was the first major route through the Appalachian Mountains. It was discovered in 1750 by Dr. Thomas Walker, and it quickly became a popular route for settlers traveling from Virginia to Kentucky. The Cumberland Gap is located in present-day southeastern Kentucky, and it is part of the Cumberland Gap National Historical Park.
2. Potomac River
The Potomac River was another important route through the Appalachian Mountains. It was used by Native Americans for centuries, and it was later used by European settlers traveling from the East Coast to the Ohio River Valley. The Potomac River is located in present-day Maryland, West Virginia, Virginia, and the District of Columbia.
3. Mohawk Valley
The Mohawk Valley was a third important route through the Appalachian Mountains. It was used by Native Americans for centuries, and it was later used by European settlers traveling from New York to the Great Lakes region. The Mohawk Valley is located in present-day New York State.