* Hernando de Soto and his expedition spent the winter of 1540–1541 near present-day Memphis.
* De Soto's expedition reached the Mississippi River near present-day Memphis in 1541.
1673
* Jacques Marquette and Louis Jolliet explored the Mississippi River and reached present-day Memphis.
1769
* Daniel Boone explored present-day Tennessee and Kentucky.
1770
* James Robertson and a group of settlers founded the Watauga Association, the first permanent European settlement in present-day Tennessee.
1772
* Robertson and other settlers founded Fort Nashborough, which later became Nashville.
1776
* The Watauga Association declared its independence from North Carolina and became the State of Franklin.
1790
* Tennessee was admitted to the Union as the 16th state.