For non-smokers, travel to Las Vegas became more palatable when the Nevada Clean Indoor Air Act passed in November 2006. The law states that people may smoke only on casino floors, in stand-alone bars that don't serve food and in strip clubs. So while no casinos are totally smoke-free, the act pushed resort casinos to make strides in offering less smoky options for gamblers. Several hotels noted for being non-smoker-friendly were mentioned in "The Seattle Times" article "Breathing Las Vegas: A smoke-sensitive tourist on a statewide smoking ban."
Many casinos use a concept called "pathing" that helps non-smokers by guiding them through the casinos away from the smoking areas with signs and paths on the carpet. Bellagio also has non-smoking areas for slots and other gaming, plus non-smoking poker rooms, which most hotels have. Cindy Ortega of the MGM-Mirage Corp., the company that owns Bellagio, was quoted in "The Seattle Times" article "Breathing Las Vegas: A smoke-sensitive tourist on a statewide smoking ban" as saying that the air is refreshed 12 times an hour, the most of any casino on the strip.
The Mirage also uses "pathing," directing guests away from the smoke with less smoky paths through the casino. The Mirage also offers large non-smoking gaming areas, including poker rooms, tables and slots, per Mirage guest relations. If you see an open table, you may request from the dealer that the table be designated smoke-free while you play. You can ask most dealers at the major casinos on the Strip to keep an open table smoke free and they will comply.
Harrah's, in the heart of the Strip, offers one of the largest non-smoking gaming areas at 1,000 square feet, states Trails.com. As a plus, more than 80 percent of Harrah's guest rooms are non-smoking as well, per Harrah's Entertainment Media Relations.
Just off the Strip on Flamingo Road is the Westin Casuarina. The entire hotel, except the casino, is smoke-free, per the hotel's website, so the casino floor should attract fewer smokers in theory.