How long does it take to drive from Hilton Head SC Topeka Kansas?

There is no direct route from Hilton Head, SC to Topeka, KS. The closest major cities to Topeka, KS are Kansas City, MO and St. Louis, MO. The drive from Hilton Head, SC to Kansas City, MO is approximately 12 hours and the drive from Hilton Head, SC to St. Louis, MO is approximately 14 hours.