The road distance from Chattanooga, Tennessee to Grand Canyon National Park (South Rim) is approximately 1,715 miles (2,760 km).
I-24 W → I-40 W (through Nashville, Memphis, Little Rock, Oklahoma City, Amarillo) → US-180 W / AZ-64 N to Grand Canyon Village. ~25–27 hours driving time (non-stop).
I-40 W to Flagstaff → US-180 N to AZ-64 N (through Sunset Crater, Wupatki). Adds ~30 mi but spectacular.
An epic cross-country journey from Appalachia to the Colorado Plateau.