Begin with the cruise itself. Be sure to avoid known periods of rough weather, especially if you're new to cruising. Don't go into the Caribbean during autumn and don't make your first cruise a Trans-Atlantic or round the world affair.
Select a jumbo cruise ship. Modern day ships are intended to be large, floating resorts and carry thousands of passengers happily to their destination. As such, they have stabilizers incorporated into their design to stop the boat from rocking. Even without the stabilizers, the larger the vessel is, the less the impact of the waves will be.
Choose a cabin in the middle. When you look at a diagram of the ship, try to put your finger on the very center. Get a room as close to that location as possible.
Stock up on over-the-counter remedies, such as Dramamine, before you board. Many ships give away sea sickness medication, but just in case it's probably best to have your own supply. If you're prone to motion sickness, take your first dose 30 minutes before you even get on the ship.
Ask your medical care provider about the scopolamine patch. This inconspicuous bit of adhesive is worn just behind the ear and will prevent seasickness for an average of 3 days. It is only available by prescription and should be applied at least 8 hours prior to departure.
Stay busy. Once you're on the boat, keep your mind occupied by getting involved in the myriad of activities made available to you during your cruise.
Walk the deck. The fresh air will do you good and the movement will help the fluid in you inner ear to stabilize and adjust to the way the ship moves. Keep your focus on the horizon when walking the deck, as this lessens the dizzying effect.
Snack on stomach-settling foods. Between meals, grab a handful of crackers, wedges of green apples, or slices of candied ginger. Wash it down with cola, ginger ale or lemon-lime flavored soda.