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- Independence Hall: This historic building was where the Declaration of Independence and the United States Constitution were signed. It is now a UNESCO World Heritage Site.
- Carpenter's Hall: This building was the meeting place of the First Continental Congress in 1774. It is now a museum dedicated to the history of Philadelphia.
- Christ Church: This Anglican church was founded in 1695 and is the oldest surviving church building in Philadelphia. It is also the burial place of Benjamin Franklin.
- The State House (now Independence National Historical Park): This building served as the Pennsylvania State House from 1735 to 1776 and was the site of the signing of the Declaration of Independence. It is now part of Independence National Historical Park.
- The Old State House: This building served as the Pennsylvania State House from 1776 to 1799 and was the site of the first two Continental Congresses. It is now a museum dedicated to the history of Pennsylvania.
- The Powel House: This historic house was built in 1765 and was the home of Samuel Powel, the mayor of Philadelphia from 1775 to 1776. It is now a museum dedicated to the history of Philadelphia.
- The Franklin Institute: This museum was founded in 1824 and is dedicated to the study of science and technology. It is home to a variety of exhibits, including the Fels Planetarium and the Benjamin Franklin National Memorial.
- The Pennsylvania Hospital: This hospital was founded in 1751 and is the oldest hospital in the United States. It is still in operation today and is known for its high-quality medical care.
- The University of Pennsylvania: This university was founded in 1740 and is one of the oldest universities in the United States. It is known for its strong academic programs and its beautiful campus.