Choose a rental car company. You can compare rates from numerous companies by using the Travelocity or Expedia websites. Before starting your search, specify that you want to look for a car only.
Go to the website of the rental car company you chose. Choose a site in Florence--probably the airport--where you'd like to pick up your rental car. Decide whether you want to return the car in Florence or elsewhere. You can return the car in Rome, for example, but there may be an additional fee.
Select the car you want and complete the payment process. Depending on the car rental company, paying online may get you a better rate than paying when you pick up the car.
Pick up your car on time. If you are going to be late, call the rental company in advance. If you are flying into Florence, give the company your flight number so it can see if your flight is delayed.
Provide your driver's license upon arrival to the car rental counter. You can review the rental company's insurance plan and select additional insurance at that time.