Choose a type of trailer: refrigerator truck for perishables, box truck, bus, dry bulk, dump truck, a tanker for liquids or some bulk dry goods, a flatbed truck for high or wide shipments, car hauler, or a lowboy which has a secondary lower level that rides closer to the road, often used to carry taller loads.
Choose your truck. There aren't many big manufacturers of large-haul semi-trucks; Freightliner, Sterling, Mack, Kenworth, Peterbilt, and Volvo. All of these trucks will come with the same hitch to attach the specified trailer for the particular cargo.
Choose a trailer brand. Trailer manufacturers develop separately from truck manufacturers. Some trailer companies include Doonan, Heil, Fontaine, J and J, and Great Dane, to name a few.
Find a dealer or private party to purchase a semi-truck and a trailer from. Rental agencies are also readily available.