Choose your backpack carefully, and plan to pack only as much as you can comfortably carry on your own within one pack.
Consider purchasing a large duffel bag in which to put your backpack when checking it on flights or carrying it on public transport. This will protect your bag and straps from damage, as well as deter against theft.
Consult Web sites and guidebooks for suggested packing lists tailored to the country you will be visiting and the activities you will be participating in.
Talk to your physician or a travel doctor for a suggested list of medications and first-aid items.
Make your own packing list after doing your research and stick with it.
Pack clothing that is essential and avoid items that you may need only once or are bringing "just in case." Choose fabrics that can be washed by hand easily and be dried on a line; don't bring items that require dry cleaning or ironing.
Bring items that are in good condition and are of good enough quality to withstand many washings and wearings. Choose colors that can be mixed and matched, preferably colors that won't show stains.
Plan on layering clothing if you will need to dress for warmth, rather than packing bulky warm items. Try out your layering system before making final packing decisions and make certain you can easily fit items over one another.
Roll your clothing into tight tubes to use packing space most efficiently and to keep clothes from wrinkling.
Separate your clothing and other items into different-colored stuff sacks by categories such as "socks and underwear," "pants," "warm layers," "gifts." This will make it easier to locate items without having to unpack everything.
Use airtight freezer bags for anything that may leak or spill. Anything liquid or gel-like will most likely end up oozing out during your flight.