Look for evidence of bedbug infestation in your luggage. If you see small, brown bugs crawling in your luggage or bug skins littering the corners of your luggage, you likely have bedbugs in your luggage. Look for evidence of bedbug feces also.
Take the luggage outside immediately if you suspect bedbugs. Empty the luggage of all clothing and other items and set these items aside until you can clean them.
Use the dry scrub brush to scrub at every nook and cranny of the luggage. Try to remove every bit of debris from the luggage corners and pockets.
Vacuum the luggage thoroughly to suck up every bit of bedbug debris, including dead bedbugs and eggs.
Place the luggage into a hot automobile (at least 120 degrees F) and leave the luggage there for at least two hours. Alternatively, if temperatures are below freezing, leave the luggage outside in freezing temperatures for at least two weeks.
Launder every piece of clothing that was in the luggage. You may even wish to launder the clothing in a laundromat without bringing it into your house at all until the clothing is clean.
Vacuum and clean any other items that you had in your luggage. If there are some that cannot be washed in a washing machine, place these items into the hot automobile or the freezing temperatures along with the luggage to remove the bedbugs.